Th17/1-Biased Inflammatory Environment Involved in the Response of Epithelial Cells to Antigen Stimuli in Nasal Polyps

Figure 1

Increased IL-17A in NP tissues. (a) Summary data showed the concentrations of IL-17A and IFN-γ in the homogenates of NP () and uncinate () tissues. (b) Summary data showed mRNA expression of IL-17A and IFN-γ in NP () and uncinate () tissues. (c) Representative microphotographs of CD3 (red)-, IL-17 (green)-, and DAPI (blue)-stained section of NP tissues. Scale bars represent 50 mM. (d) The mononuclear cells from NP and uncinate tissues were cultured with or without anti-CD3 plus anti-CD28 for 24 h. Representative ELISpot results of IL-17A- and IFN-γ-producing cells were shown. (e) Summary ELISpot results of IL-17A- and IFN-γ-producing cells were shown (). Data were shown as the . Statistical significance was determined with the Mann–Whitney test. ; ; ns: no significance; NP: nasal polyp; UN: uncinate.

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