The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells

Figure 3

Effects of tamoxifen, celastrol, and the combination of tamoxifen and celastrol on apoptosis in MCF-7 cells. After treatment with celastrol (0.3 μM), TAM (1, 3, and 10 μM), and the combination for 24 hours, cell apoptosis was detected. The lower concentration of celastrol (0.3 μM) did not increase apoptosis in MCF-7 cells; the medium-high concentration of TAM (3, 10 μM) significantly increased the apoptosis rate of MCF-7 cells, and even the addition of celastrol at a lower concentration significantly increased cell apoptosis.

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