The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells

Figure 7

Effects of tamoxifen, celastrol, and the combination of tamoxifen and celastrol in MCF-7 tumour-implanted athymic BALB/c nude mice. The tumour-bearing mice were sacrificed on day 15. Representative photographs (a, b) of gross tumours in the mice in the vehicle, CEL, TAM, and CEL+TAM groups. Body weight (c), tumour volume (d), and tumour weight (e) were significantly decreased in the CEL+TAM group compared with the tamoxifen alone group.

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