ERO1L Promotes Hepatic Metastasis through Activating Epithelial-Mesenchymal Transition (EMT) in Pancreatic Cancer

Figure 1

ERO1L is overexpressed in metastatic PDAC and predicts a poor prognosis. (a) The expression pattern of ERO1L in paired samples of three independent PDAC cohorts using GSE16515 (, ), GSE15471 (, ), and GSE102238 (, ). Data were derived from the GEO database. (b) The expression pattern of ERO1L in hepatic metastatic PDAC cohort using GSE151580 (, ). Data were derived from the GEO database. (c) Representative images of ERO1L protein expression in two hepatic metastatic PDAC patients; Scale bar: 50 μm. (d) Kaplan-Meier survival curves showing the overall survival of PDAC patients based on ERO1L expression in TCGA-PAAD datasets (log-rank test, ). (e) Kaplan-Meier survival curves showing the disease-free survival of PDAC patients based on ERO1L expression in TCGA-PAAD datasets (log-rank test, ).

(a)

(b)

(c)

(d)

(e)