Crosstalk between RNA-Binding Proteins and Immune Microenvironment Revealed Two RBP Regulatory Patterns with Distinct Immunophenotypes in Periodontitis

Figure 1

Expression landscape of RNA binding proteins (RBPs) in periodontitis. (a) The overview of RBPs’ regulatory role in periodontitis. (b) A summary of the types of RNA which the RBPs were binding to. (c) The volcano plot demonstrated the differentially expressed RBPs in periodontitis and periodontally healthy samples. RBPs with adjust value < 0.01 and were considered to be significantly dysregulated, and their gene names were marked. The box plot (d) and heatmap (e) demonstrated the expression status of the 24 dysregulated RBPs between periodontally healthy and periodontitis samples. (f) The protein-protein interaction network of the 24 dysregulated RBPs. (g) The correlation among the 24 significantly dysregulated RBPs in periodontitis samples and whole samples. The most correlated RBPs in all samples and periodontitis samples were demonstrated in the dot plot.

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