Crosstalk between RNA-Binding Proteins and Immune Microenvironment Revealed Two RBP Regulatory Patterns with Distinct Immunophenotypes in Periodontitis

Figure 4

Immune-related pathways in periodontitis and their correlation with RBPs. (a) Correlation analysis between activities of immune pathways and RBPs expression levels. (b) Dot plot and box plot reveal the relationship between the most positively correlated immune pathway-RBP pair, BCR signaling pathway, and ISG20. A higher activity of BCR signaling pathway and higher expression of ISG20 were observed in periodontitis samples. (c) Dot plot and box plot reveal the relationship between the most negatively correlated immune pathway-RBP pair, BCR signaling pathway, and ESRP1. A higher activity of BCR signaling pathway and lower expression of ESRP1 were observed in periodontitis samples.