Crosstalk between RNA-Binding Proteins and Immune Microenvironment Revealed Two RBP Regulatory Patterns with Distinct Immunophenotypes in Periodontitis

Figure 6

Unsupervised clustering of periodontitis samples based on the RBP expression. (a) Consensus clustering cumulative distribution function (CDF) for –7. (b) Relative change in area under the CDF curve for –7. (c) Heatmap of the matrix of cooccurrence proportions for periodontitis samples. (d) Principle component analysis (PCA) of the two RBP regulatory subtypes. (e) Clinical features of the two RBP regulatory subtypes. (f) Expression of subtype-specific RBPs. The subtype-specific RBPs were the differentially expressed RBPs between the two RBP regulatory subtypes (adjust value < 0.01, ). (g) Heatmap of the expression of subtype-specific RBPs.

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