Transcriptional Profiling Reveals Kidney Neutrophil Heterogeneity in Both Healthy People and ccRCC Patients

Figure 5

Analysis of integrated neutrophil of healthy kidney and ccRCC. (a) UMAP plot shows “Merged” healthy kidney neutrophils and ccRCC neutrophils based on all the genes detected. (b) UMAP plot shows 6 neutrophil subclusters of integrated neutrophils based on conserved genes. (c) Dot plots show the differential expression levels of the most significant genes for each cluster. (d) GSEA analysis of each integrated neutrophil subcluster. (e) Expression levels of CTLA-1, PD-1, and PD-L1 in ccRCC neutrophils.

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