Neuromedin U Suppresses Collagen-Induced Arthritis through ILC2-Th2 Activation

Figure 1

NMU-23 inhibited joint inflammation and bone erosion in CIA mice. (a) Representative hind paw of mice from WT control (), WT treated with NMU-23 (), and WT treated with PBS (). (b) Clinical assessment of CIA mice determined every 2 days ( each in two independent experiments). (c) Representative hematoxylin-eosin (H&E) and tartrate-resistant acid phosphatase (TRAP) staining of the knee joint and hind paw of mice. (d, e) Quantification of histological score and number of osteoclasts in the knee joint (d) and hind paw (e) of mice. Data are shown as ( and determined by Student’s -test).

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