Neuromedin U Suppresses Collagen-Induced Arthritis through ILC2-Th2 Activation

Figure 4

NMU-deficient mice developed significantly less severe arthritis. (a) Clinical assessment of NMU^+/+ and NMU^-/- CIA mice ( each in two independent experiments) determined every 2 days. (b) Quantification of histological score and number of osteoclasts in the knee joint and hind paw of mice. (c) The frequency of ILC2 in the joint, mLN, and spleen of arthritic mice. (d) The frequency of Treg in the joint, mLN, and spleen of arthritic mice. (e, f) mRNA expression of FoxP3, Gata3 (e), IL-4, IL-5, and IL-13 (f) in the joint of WT and NMU^-/- mice. Data are shown as ( and determined by Student’s -test).

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