Neuromedin U Suppresses Collagen-Induced Arthritis through ILC2-Th2 Activation

Figure 5

Mechanisms of suppression of arthritis induced by NMU. NMU stimulated ILC2 and subsequently activated Th2, leading to the production of IL-4, IL-13, and IL-5. These type 2 cytokines further activated eosinophils and anti-inflammatory M2 macrophages, together with decreased neutrophil activity, promoting resolution of arthritis.