VDR Polymorphisms in Autoimmune Connective Tissue Diseases: Focus on Italian Population

Table 2

Association between disease phenotypes and studied polymorphisms.

Disease	Phenotype	^a	OR (95% CI)
rs2228570 C > T Fok1
Systemic lupus erythematosus	C3 (below normal values)	0.003	0.36 (0.18-0.71)
	C4 (below normal values)	0.021	0.45 (0.23-0.89)
Rheumatoid arthritis	Seropositivity	0.034	0.33 (0.12-0.96)
rs7975232 T > G Apa1
Systemic lupus erythematosus	Neuropsychiatric SLE	0.023	2.24 (1.11-4.54)
	Anti-dsDNA	0.024	0.52 (0.30-0.92)
	Anti-RNP	0.05	1.97 (0.99-3.92)
	Anti-Ro/SSA	0.035	1.87 (1.04-3.38)
	Anti-La/SSB	0.037	2.16 (1.04-4.50)
Primary Sjogren syndrome	Anti-Ro/SSA	0.033	0.47 (0.23-0.95)
	Seropositivity	0.043	0.49 (0.24-0.99)
rs731236 A > G Taq1
Systemic lupus erythematosus	Leucopenia	0.024	0.49 (0.26-0.92)
	Nephritis	0.032	0.42 (0.19-0.95)
	Neuropsychiatric SLE	0.037	0.24 (0.06-1.02)
	Anti-La/SSB	0.027	2.41 (1.09-5.33)
	Seropositivity	0.045	1.96 (1.01-3.81)
Primary Sjogren syndrome	Parotid swelling	0.014	2.84 (1.20-6.70)

^a value refers to the analysis based on the recessive model (homozygous variant genotypes vs. others).