Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice

Figure 7

Serum cytokines in USP21^fl/flFOXP3^Cre mice infected with S. japonicum. (a) Comparison of the concentrations of IFN-gamma, IL-4, IL-10, IL-17A, IL-23, and IL-9 in the cultures of peripheral blood lymphocytes isolated from the WT and KO mice in the NC and INF groups 42 days after the infection ( mice/group). The data are presented as the , IL-4 , and IL-23 for the comparison between the infection groups. (b) Comparison of the serum IFN-gamma, IL-4, IL-10, IL-17A, IL-23, and IL-9 levels in the WT- and KO-INF groups (/group) at different time points (uninfected, 20^th day after infection, 30^th day after infection, and 42^nd day after infection). The data are presented as the . IFN-γ on day 20 and on day 42; IL-10 on day 20 and on day 30; IL-17A on day 20, on day 30, and on day 42; IL-23 on day 30; and IL-9 on day 42.

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