The Role of β-Catenin in Th1 Immune Response against Tuberculosis and Profiles of Expression in Patients with Pulmonary Tuberculosis

Figure 2

The expression of IFN-γ and TNF-α in CD3⁺ and CD4⁺ T cells. (a, b) IFN-γ⁺CD4⁺ T cell in the lungs and spleens of Ctnnb1^-/- mice () and wild-type mice () infected with or without M. tuberculosis. (c, d) TNF-α⁺CD4⁺ T cell in lungs and spleens of Ctnnb1^-/- mice () and wild-type mice () infected with or without M. tuberculosis. (e, f) CD69⁺CD3⁺CD4⁺ T cells in the lungs and spleens from Ctnnb1^-/- mice () and wild-type mice () infected with or without M. tuberculosis. (g, i) mRNA of IFN-γ, TNF-α, and TCF-7 in the lungs of Ctnnb1^-/- mice () and wild-type mice () infected with or without M. tuberculosis. The experiment had three independent rounds, and results were analyzed by the unpaired Student -test. PBS, phosphate-buffered saline.

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