p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway

Figure 3

p75NTR/proBDNF controls RIPK1/RIPK3-induced necroptosis. (a) Western blot analysis of p-RIPK1, p-RIPK3, and p-MLKL protein levels inTE354.T-P75NTR and ASZ010-p75NTR cells treated with or without proBDNF plus 20 ng/mL TNF. (b) TE354.T-P75NTR and ASZ010-p75NTR cells stabilized expressed with fused GFP were treated with or without proBDNF plus 20 ng/mL TNF. Necroptotic cell death was monitored by staining with cytotoxic red and monitored by Incucyte.

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