Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis

Figure 2

In situ detection of insulin-like growth factor (IGF)-I and Leishmania antigens in the inflammatory infiltrate of cutaneous leishmaniases lesions caused by L. (Viannia) braziliensis. IGF-I (brown) and Leishmania antigens (red) are expressed in normal skin (a) and cutaneous leishmaniases lesions (b–e). IGF-I is present in the basal layer in normal skin (a) and in CL lesions (b). In CL lesions, IGF-I is present in the dermis (c). IGF-I was observed close to Leishmania antigens in the dermis (d). Leishmania antigens were observed in the dermis (e). Representative photos of immunohistochemical analysis. Original magnification ×400.

(a)

(b)

(c)

(d)

(e)