Antigen-Specific Tissue-Resident Memory T Cells in the Respiratory System Were Generated following Intranasal Vaccination of Mice with BCG

Figure 7

BCG-induced tissue-resident memory T cells persisted for a long period of time in the lavage fluids, nasal mucosa, trachea, and lungs. (a, b) () After intranasal vaccination of mice with BCG for one and three months, the proportion of CD44^highCD4⁺CD69⁺, CD44^highCD4⁺CD103⁺, CD44^highCD8⁺CD69⁺, and CD44^highCD8⁺CD103⁺ T cells and the expression of antigen specific IFN-γ in the four groups of CD69^−/+CD103^−/+ T cells on CD4⁺ and CD8⁺ T cells were analyzed as . The results representing four independent experiments for five mice each group were shown and compared with two-way ANOVA. and ; ns: no significance.

(a)

(b)