Invariant Natural Killer T Cells as Key Players in Host Resistance against Paracoccidioides brasiliensis

Figure 4

iNKT cells deficiency is associated with the accumulation of suppressor myeloid-derived cells in the lungs of P. brasiliensis infected mice. WT and Jα18^-/- C57BL/6 mouse strains were infected with Pb18 yeasts, and 72 h later, the lung parenchyma was analyzed for: Frequency of (a) GR1⁺CD11b⁺SCC^high and (b) GR1⁺CD11b⁺SCC^low myeloid-derived cells. Frequency of MHC-II-expressing cells within (b) GR1⁺CD11b⁺SCC^high and (e) GR1⁺CD11b⁺SCC^low subsets and MHC-II surface expression level (c, f, respectively). Expression levels of CD11b molecules within the (g) GR1⁺CD11b⁺SCC^high and (h) GR1⁺CD11b⁺SCC^low myeloid-derived cells subsets. Data represent the from 1 of 2 independent experiments (/group). .

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