RNA-seq and In Vitro Experiments Reveal the Protective Effect of Curcumin against 5-Fluorouracil-Induced Intestinal Mucositis via IL-6/STAT3 Signaling Pathway

Figure 3

Effect of curcumin on the cloning ability and migration of the 5-FU-stimulated IEC-6 cells. IEC-6 cells were stimulated with 5-FU for 24 h and then further treated with curcumin at 5, 10, and 20 μmol/L for 24 h. (a) Colony formation assay was performed to detect the cell colony ability of each group cells. (b) Wound healing assay was performed to detect the cell migration distance from 0 h to 24 h of each group cells. Data were expressed as (SEM), ^▲▲ value < 0.01 vs. control group; value < 0.05 vs. 5-FU group; value < 0.01 vs. 5-FU group. 5-FU: 5-fluorouracil.

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