Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility

Figure 6

The expression and correlation of CXCR2 evaluated by the Gene Set Enrichment Analysis (GSEA) and STRING tools. More than 10 proteins can be involved in the interaction with CXCR2 protein. They were interleukin-8 (CXCL8), C-X-C motif chemokine 5 (CXCL5), growth-regulated alpha protein (CXCL1), C-X-C motif chemokine 2 (CXCL2), platelet basic protein (PPBP), C-X-C motif chemokine 6 (CXCL6), C-X-C motif chemokine 3 (CXCL3), stromal cell-derived factor 1 (CXCL12), C-X-C chemokine receptor type 1 (CXCR1), and C-C motif chemokine 5 (CCL5) (a). Plot of normalized enrichment score (NES) versus false positive rate (FDR) (b). GSEA showed evidence that the expression of CXCR2 is correlated with pathways in cancer ((c), ). Signaling pathways, including mitogen-activated protein kinase (MAPK) signaling (d) and calcium signaling system (e), were associated with the high expression of CXCR2.

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