Ion Transport Modulators Differentially Modulate Inflammatory Responses in THP-1-Derived Macrophages

Table 1

Concentrations of drugs tested in the current study and their maximum free plasma concentrations in humans when taken at therapeutic doses.

Drug	Concentration used in the current study in ng/ml	Maximum free plasma concentration in ng/ml
Ambroxol HCl	6	6 [13]
Amiloride HCl	40	40 [14]
Diazoxide	5000	5000 [15]
Digoxin	2	2 [16]
Furosemide	500	500 [17]
HCTZ	500	642 [18]
Metformin	1000	1000 [19]
Omeprazole	200	200 [20]
Pantoprazole	180	180 [21]
Phenytoin	2000	2000 [22]
Verapamil	24	24 [23]
Drug X	2	2
Drug Y	2	2

Note. Reprinted from “Ion Transport Modulators as Antimycobacterial Agents,” by SC Mitini-Nkhoma et al. 2020, Tuberculosis Research and Treatment, vol. 2020, doi:10.1155/2020/3767915.