Ion Transport Modulators Differentially Modulate Inflammatory Responses in THP-1-Derived Macrophages

Table 3

Summary of immunomodulatory activity of ion transport modulators.

	Nitric oxide	Superoxide	TNF-α	IL-1β	IL-10	IL-12α
Ambroxol HCl	↓	↓	↔	↔	↔	↔
Amiloride HCl	↑	↓	↑	↑	↔	↔
Diazoxide	↓	↓	↑	↑	↔	↔
Digoxin	↓	↓	↑	↑	↔	↔
Furosemide	↓	↓	↑	↑	↔	↔
HCTZ	↓	↓	↔	↔	↔	↔
Metformin	↓	↓	↑	↔	↔	↔
Omeprazole	↔	↓	↔	↔	↔	↔
Pantoprazole	↓	↓	↑	↔	↔	↔
Phenytoin	↓	↓	↑	↑	↔	↔
Verapamil	↓	↓	↑	↑	↔	↔
X	↔	↓	↑	↑	↔	↔
Y	↓	↓	↑	↑	↔	↔