Knockdown of lncRNA CCAT1 Inhibits the Progression of Colorectal Cancer via hsa-miR-4679 Mediating the Downregulation of GNG10

Figure 6

sh-CCAT1 inhibited the CRC progression in vivo via the miR-4679/GNG10 axis. (a) The size of tumor tissues was significantly decreased after sh-CCAT1 using HT-29 and HCT-116 cells. (b) The statistical result of the tumor volume. (c) H&E staining was performed to detect the damages after the treatment with sh-CCAT1. (d) Ki-67 staining was performed to detect the proliferation status of the tissues after sh-CCAT1. (e) The ratio of Ki-67-positive cells. (f) WB was performed to detect the levels of proliferation markers. (g) WB was performed to detect the levels of pro- and antiapoptotic proteins. (h) Relative expression of hsa-miR-4679 after sh-CCAT1 in vivo. (i) Relative expression of GNG10 after sh-CCAT1 in vivo. and .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)