Research Article

Predictive Significance of the Prognostic Nutritional Index (PNI) in Patients with Severe COVID-19

Table 1

Clinical characteristics of patients with COVID-19 in the training and validation cohorts.

Training cohort ()Validation cohort () value

Gender (, %)0.062
 Male116 (49.15%)37 (62.71%)
 Female120 (50.85%)22 (37.29%)
Age (years)61 (48,71)60 (47.69)0.550
History (, %)
 Hypertension70 (29.67%)15 (25.42%)0.520
 DM36 (15.25%)8 (13.56%)0.744
Symptoms (, %)
 Fatigue104 (44.07%)27 (45.76%)0.815
 Headache15 (6.36%)3 (5.08%)0.952
 Cough152 (64.41%)42 (71.19%)0.326
 Dyspnea67 (28.39%)19 (32.20%)0.564
 Diarrhea27 (11.44%)6 (10.17%)0.774
Signs
 Temperature36.70 (36.50, 37.00)36.60 (36.40, 37.00)0.548
 HR (bpm)86 (80, 98)88 (81, 98)0.336
 RR (/min)20 (19, 24)20 (20, 25)0.552
Laboratory indices
 WBC counts (109/L)6.29 (4.46, 9.37)5.37 (3.96, 8.02)0.105
 NEU counts (109/L)6.51 (3.56, 50.3)5.14 (3.12, 29.41)0.244
 LYM counts (109/L)1.21 (0.72, 5.33)1.16 (0.72, 2.77)0.886
 MON counts (109/L)0.53 (0.37, 2.33)0.53 (0.33, 1.15)0.764
 NLR4.62 (2.32, 10.02)3.78 (1.79, 9.11)0.406
 HGB (g/L)125.00 (115.00, 137.00)130.00 (119.00, 143.00)0.088
 PLT (109/L)199.50 (141.80, 262.30)205.00 (156.00, 252.00)0.529
 ALB (g/L)35.10 (32.00, 39.40)37.00 (32.30, 40.00)0.308
 PNI36.19 (33.23, 39.78)37.00 (32.30, 40.00)0.916
 ALT (U/L)26.50 (17.30, 43.00)27.00 (16.50, 41.50)0.689
 AST (U/L)31.00 (22.00, 46.00)30.00 (21.00, 38.50)0.460
 GLU (mmol/L)5.90 (5.02, 7.79)5.56 (4.77, 6.79)0.059
 LDH (U/L)296.50 (211.00, 432.50)273.00 (220.00, 420.00)0.825
 P/F ratio (mmHg)168.85 (100.42, 289.75)231.42 (131.11, 342.00)0.120
CURB651.0 (0, 1.0)1.0 (0, 1.0)0.931
APACHE II6.0 (3.0, 10.0)6.0 (3.0, 10.0)0.600
SOFA2.0 (1.0, 4.0)1.0 (0, 3.0)0.143
Death (, %)63 (26.69%)14 (23.73%)0.643

Abbreviations: DM; diabetes mellitus; WBC: white blood cells; NEU: neutrophils; LYM: lymphocytes; MON: monocytes; NLR: neutrophil-lymphocyte ratio; HGB: hemoglobin; PLT: platelet; ALB: albumin; PNI: prognostic nutritional index; ALT: alanine transaminase; AST: aspartate aminotransferase; LDH: lactic dehydrogenase; P/F ratio: PaO2/FiO2 ratio; CURB65: confusion, uremia, respiratory rate, blood pressure; APACHE II: Acute Physiology and Chronic Health Evaluation II; SOFA: sequential organ failure assessment.