Effects of Immune System-Related Medications on COVID-19 Outcome in a Cohort of Iranian Patients: Preliminary Report of a Data Mining Study

Table 4

Logistic regression model for association of hydroxychloroquine with death and the significant interactions.

Model	Step 1: adjusted with each other		Step 2: step 1 plus interactions
Covariates	Adjusted odds ratio (95% CI)	value	Adjusted odds ratio (95% CI)	value
Age	1.038 (1.034, 1.042)	<0.001	1.044 (1.038, 1.050)	<0.001
ICU	3.428 (2.981, 3.941)	<0.001	7.590 (4.354, 13.233)	<0.001
Underlying drugs	2.348 (1.996, 2.762)	<0.001	1.869 (1.461, 2.391)	<0.001
Hydroxychloroquine (HCQ)	0.794 (0.689, 0.916)	0.002	0.600 (0.453, 0.794)	<0.001
Significant interactions
Age #ICU			0.988 (0.980, 0.996)	0.004
Underlying drugs #HCQ			1.464 (1.057, 2.029)	0.022

Significant at 0.05. #Interaction sign.