Effects of Immune System-Related Medications on COVID-19 Outcome in a Cohort of Iranian Patients: Preliminary Report of a Data Mining Study

Table 5

Logistic regression model for association of dexamethasone with death and the significant interactions.

Model	Step 1: adjusted with each other		Step 2: step 1 plus interactions
Covariates	Adjusted odds ratio (95% CI)	value	Adjusted odds ratio (95% CI)	value
Age	1.038 (1.034, 1.042)	<0.001	1.044 (1.038, 1.050)	<0.001
ICU	3.335 (2.898, 3.838)	<0.001	7.448 (4.266, 13.005)	<0.001
Underlying drugs	2.259 (1.919, 2.660)	<0.001	2.245 (1.907, 2.643)	<0.001
Dexamethasone	1.181 (1.020, 1.368)	0.026	1.183 (1.022, 1.369)	0.025
Significant interactions
Age #ICU			0.988 (0.980, 0.996)	0.003
Interaction not assumed
ICU #dexamethasone			0.795 (0.595, 1.060)	0.119

Significant at 0.05. #Interaction sign.