Vitamin D Regulates the Expression of Glucocorticoid Receptors in Blood of Severe Asthmatic Patients

Figure 4

Vitamin D treatment increases the expression of GR-α with no effect on GR-β. Asthmatic subjects were treated with 50,000 IU of vitamin D orally or placebo for eight weeks. Blood specimens obtained prior to and following 8 weeks of treatment were analyzed for mRNA expression of (a) GR-α and (b) GR-β using RT-qPCR, and the ratio of (c) GR-α/GR-β was calculated. .

(a)

(b)

(c)