Exosomal miR-452-5p Induce M2 Macrophage Polarization to Accelerate Hepatocellular Carcinoma Progression by Targeting TIMP3

Figure 2

miR-452-5p inhibition suppressed HCC cell migration and invasion. (a) miR-452-5p expression in HCC cells and normal human epithelial cells. (b) miR-452-5p was successfully inhibited by the miR-inhibitor. (c, d) CCK-8 assay and EdU staining of HCC cells with and without miR-452-5p inhibition. Optical density (OD) was measured at 24, 48, and 72 h after transfection. (e) Apoptosis rate was analyzed by flow cytometry. (f, g) Migration and invasion were detected by Transwell assay. .

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