Plasma CXCL3 Levels Are Associated with Tumor Progression and an Unfavorable Colorectal Cancer Prognosis

Table 2

Associations among preoperative plasma CXCL3 levels and clinical parameters of CRC patients.

Clinicopathological characteristics	Total ()	Expression of CXCL3		value
		High ()	Low ()
Sex				0.853
Female	71	39	32
Male	157	91	66
Age (years)				0.691
≥ 60	155	88	67
< 60	73	39	34
Tumor site				1.347
Left colon	49	38	11
Right colon	78	32	46
Rectum	101	57	44
Tumor size (cm)				0.034
≥ 5	142	74	68
< 5	86	52	34
Staging				<0.001
І + II	76	42	34
III	132	75	57
IV	20	11	9
Tumor stage				0.003
T1 + T2	9	6	3
T3	179	108	71
T4	40 29	24	16
Differentiation				0.001
CRC, WD	9	6	3
CRC, MD	96	53	43
CRC, PD	123	81	42
Lymph node metastasis				0.007
N0	81	43	38
N1	58	45	13
N2	89	70	19
Distant metastasis				1.218
M0	199	110	89
M1	29	18	11

CXCL3: CXC-chemokine ligand 3; TNM, tumor (T), nodes (N), and metastases (M). CRC: colorectal cancer; CRC WD: well-differentiated cancer; CRC MD: moderately differentiated cancer; CRC PD: poor-differentiated cancer.