Research Article
Age-Stratified Analysis of Vaginal Microbiota Dysbiosis and the Relationship with HPV Viral Load in HPV-Positive Women
Table 1
Characteristics of 388 HPV-positive women in different age distribution (
(%)).
| | <50
| ≥50
| value |
| | Age | | | | | 41.5 (±10.7) | | | Menopause status | 6 (1.9) | 76 (93.8) | <0.001 | | Biopsy | | | | | Normal | 34 (11.1) | 14 (17.3) | 0.452 | | LSIL/CIN1 | 38 (12.4) | 9 (11.1) | | HSIL/CIN2 | 86 (28.0) | 19 (23.5) | | HSIL/CIN3 | 122 (39.7) | 29 (35.8) | | SCC/AIS | 27 (8.8) | 10 (12.3) | | Cytology | | | | | NILM | 160 (52.1) | 42 (51.9) | 0.849 | | ASCUS/LSIL | 69 (22.5) | 14 (17.3) | | ASC-H+ | 78 (25.4) | 25 (30.7) | | CST type | | | | | I | 81 (26.4) | 6 (7.4) | <0.001 | | II | 3 (1.0) | 2 (2.5) | | III | 120 (39.1) | 18 (22.2) | | IV | 94 (30.6) | 54 (66.7) | | V | 9 (2.9) | 1 (1.2) | | HPV viral load | | | | | Log (all); , median (IQR) | 4.79 (3.79-5.68) | 4.60 (3.37-5.75) | 0.436 | | Log (16/18); , median (IQR) | 1.44 (0-4.82) | 1.52 (0-4.44) | 0.556 | | Log (hrHPV); , median (IQR) | 4.78 (3.68-5.66) | 4.52 (3.30-5.72) | 0.365 | | Multiple HPV types | | | | | Yes | 90 (29.3) | 30 (37.0) | 0.181 | | No | 217 (70.7) | 51 (63.0) | | HR-HPV | | | | | HPV16/18(+) | 142 (47.5) | 36 (46.2) | 0.833 | | Other HR(+) | 157 (52.5) | 42 (53.8) |
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LSIL: low-grade squamous intraepithelial lesion; HSIL: high-grade squamous intraepithelial lesion; CIN: cervical intraepithelial neoplasia; SCC: squamous cell carcinoma; AIS: adenocarcinoma in situ; NILM: negative for intraepithelial lesions or malignancy; ASCUS: atypical squamous cells of undetermined significance ASC-H: atypical squamous cell-cannot exclude HSIL; CST: community state types.
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