29 m⁶A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses

Figure 1

Flow chart of the study. Data mining work includes two parts: (I) the expression changes of m⁶A-RMRs in diseases including acute inflammation, sepsis, acute respiratory distress syndrome, shock, trauma, cardiovascular diseases (CVDs), autoimmune diseases, organ failures, and cancers were examined; (II) cellular mechanisms including macrophages and CD4⁺Foxp3⁺ regulatory T cell (Treg) modulation and molecular mechanisms including the role of danger-associated molecular pattern receptors (DAMP receptors); proinflammatory cytokines; immune checkpoint and costimulation receptors; methionine-homocysteine-methyl donation cycle enzymes; m⁶A-RMRs; proinflammatory transcription factors NF-κB and JAK/STAT; tumor suppressors TP53, PTEN, and APC; histone methyltransferases; and DNA methyltransferases in regulation of m⁶A-RMRs were explored.