29 m⁶A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses

Figure 11

Regulatory T cells regulate the expression of m⁶A-RNA methylation regulators (m⁶A-RMRs). (a) Compared with conventional T cells, expression of IGF2BP3 is upregulated and RBMX is downregulated in regulatory T cells. (b) The expression data matrix was obtained from scRNA study (PMID: 29434354), and the expression heat map using Cluster web tool (PMID: 25969447) was generated. The result showed that the expression of m⁶A-RMRs in six types of Treg clusters was different. Expression of Ythdf3 and Rbm15b have the same pattern as Treg signature gene Foxp3. (c) Most m⁶A-RMRs are downregulated in deficiencies of GATA3, HDAC6, HDAC9, IL2RB, and FOXO1. The numbers of upregulated regulators are more than those of downregulators in deficiencies of BCL6, DICER, BLIMP1, PPARG, EOS, and EP300.

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