29 m⁶A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses

Figure 12

Immune checkpoint receptors regulate the expression of m⁶A-RNA methylation regulators (m⁶A-RMRs). T cell activation can regulate the expression of m⁶A-RMRs. Microarrays about immune checkpoint knockout (KO), knockdown (KD), anticheckpoint, or sorted negative and positive checkpoint were searched from the GEO database to analyze the regulation relationship between immune checkpoint and m⁶A-RMRs. The result showed that when the coinhibitory immune checkpoints PD-L2, TIM-3, and TIGIT were inhibited (KO or KD vs. control, anti- vs. control) or reduced (negative vs. positive), the expressions of m⁶A-RMRs were decreased. However, the costimulatory immune checkpoint CD40L was inhibited, and more m⁶A-RMRs’ expressions were increased. That is, maybe, T cell activation negatively regulates the expression of m⁶A-RMRs.