29 m⁶A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses

Figure 5

The m⁶A-RNA methylation regulators (m⁶A-RMRs) were more differentially expressed in rheumatoid arthritis (RA) and autoimmune skin diseases than those in other autoimmune diseases. (a) The expression changes of m⁶A-RMRs showed the higher expression fold changes in RA and skin autoimmune diseases than those in inflammatory bowel disease. KIAA1429 and PCIF1 were highly increased; and METTL14, CBLL1, and RBM15 were highly decreased in RA; WTAP, PRRC2A, and G3BP2 were highly increased genes in skin autoimmune disease psoriasis. (b) Venn diagram showed that there were seven upregulated m⁶A-RMRs and five downregulated m⁶A-RMRs in autoimmune skin diseases. The writer WTAP and reader HNRNPA2B1 were the common increased and decreased genes in autoimmune skin diseases. There were 13 upregulated m⁶A-RMRs and 16 downregulated m⁶A-RMRs in inflammatory bowel diseases. YTHDC2 and G3BP2 were the common downregulated m⁶A-RMRs. PCIF1 was the shared upregulated m⁶A-RMR by RA and inflammatory bowel disease. CBLL1, RBM15, YTHDF3, and EIF3A were the shared downregulated m⁶A-RMRs by RA and inflammatory bowel disease. There were 19 upregulated m⁶A-RMRs and 21 downregulated m⁶A-RMRs in these three types of autoimmune diseases. Note: the red marked genes are those that are up- or downregulated in different diseases (). Abbreviations: RA: rheumatoid arthritis; ACLE: acute cutaneous lupus; CCLE: chronic cutaneous lupus; PS: psoriasis; SCLE: subacute cutaneous lupus; UC: ulcerative colitis; CD: Crohn’s disease. FC: fold change; NA: not available (missing value).

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