29 m⁶A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses

Figure 7

The m⁶A-RNA methylation regulators (m⁶A-RMRs) were upregulated in virus-infected cells as the infection time was extended. (a) In general, upregulated m⁶A-RMRs were more than downregulated m⁶A-RMRs in the condition of MERS and SARS infections. The expressions of m⁶A methylation writers such as WTAP, KIAA1429, CBLL1, and RBM15 and readers YTHDF1, YTHDF2, YTHDF3, and RBP dependent on m⁶A PRRC2A were increased; and the expression of eraser FTO was decreased when endothelial cells were infected with MERS coronavirus (MERS-CoV) and SARS coronavirus (SARS-CoV). (b) In avian influenza virus studies, it was obvious that the expressions of writer WTAP and PCIF1 were increased, and the expression of eraser FTO was decreased in all avian influenza virus-infected cells; the longer the infected time was, the higher the numbers of differentially expressed m⁶A methylation regulators there were. The results suggest that MERS coronavirus, SARS coronavirus, and avian influenza virus infections upregulated the expressions of m⁶A-RMRs (). Abbreviations: MERS: Middle East respiratory syndrome; SARS: severe acute respiratory syndrome; H1N1, H7N9, H7N7, H5N1, and H3N2 are the cell populations of avian influenza virus. FC: fold change; NA: not available (missing value).

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