29 m⁶A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses

Table 3

Eight microarray datasets about endothelial cells in different conditions in the NIH-NCBI-GeoDataset database (https://www.ncbi.nlm.nih.gov/gds/) were collected to analyze the changes of m⁶A methylation regulators.

GEO ID	Comparison	Cell/tissue	No. of samples	PMID
GSE59226	Influenza virus-infected vs. inactivate virus-infected	Human umbilical vein ECs	2/2	25863179
GSE1377	Kaposi sarcoma-associated herpes virus-infected for 7 days vs. uninfected control	Primary human dermal ECs	2/2	15220917
GSE5883	10 ng LPS stimulation for 4 hours vs. no LPS stimulation	Human lung microvascular ECs	4/4	NA
	10 ng LPS stimulation for 8 hours vs. no LPS stimulation	Human lung microvascular ECs	4/4	NA
	10 ng LPS stimulation for 24 hours vs. no LPS stimulation	Human lung microvascular ECs	4/4	NA
GSE3920	1000 IU IFNα treated for 5 hours vs. untreated control	Human umbilical vein ECs	5/5	17202376, 19553003
	1000 IU IFNβ treated for 5 hours vs. untreated control	Human umbilical vein ECs	2/5	17202376, 19553003
	1000 IU IFNγ treated for 5 hours vs. untreated control	Human umbilical vein ECs	3/5	17202376, 19553003
GSE85987	NOTCH1 siRNA vs. scrambled control siRNA	Human umbilical vein ECs	3/3	29449332
	NOTCH1 siRNA+IL-1β treated 24 hours vs. scrambled siRNA	Human umbilical vein ECs	3/3	29449332
GSE72633	NOTCH1 siRNA vs. scrambled control siRNA	Human aortic ECs	3/3	26552708
	oxPAPC treated vs. scrambled control siRNA	Human aortic ECs	3/3	26552708
GSE26953	Oscillatory shear vs. laminar shear (fibrosa)	Human aortic valvular ECs	6/6	21705672
	Oscillatory shear vs. laminar shear (ventricularis)	Human aortic valvular ECs	6/6	21705672
GSE39264	apoE KO vs. WT	Mouse aortic ECs	4/6	23990205
	LPS treated for 4 hours vs. DMEM treated for 4 hours	Mouse aortic ECs	3/3	23990205
	oxLDL treated for 4 hours vs. DMEM treated for 4 hours	Mouse aortic ECs	3/3	23990205
	oxPAPC treated for 4 hours vs. DMEM treated for 4 hours	Mouse aortic ECs	3/3	23990205

Abbreviations: LPS: lipopolysaccharide; IFN: interferon; NOTCH1: notch receptor 1; ox-PAPC: oxidized-1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine; siRNA: small interfering RNA; apoE: apolipoprotein E; KO: knockout; WT: wild type; ox-LDL: oxidized low-density lipoprotein; DMEM: Dulbecco’s modified eagle medium; No. of samples: .