Macrophage Depletion Reduces Disease Pathology in Factor H-Dependent Immune Complex-Mediated Glomerulonephritis

Figure 5

Mϕs depletion reduces glomerular pathology in FH-dependent ICGN. Given are representative images of glomeruli from saline-treated (a), apoferritin-treated (b), and apoferritin+clodronate-treated FH-deficient mice. In (A), the sections are stained with C3 (green) and IgG (red), while (B) show sections stained with PAS. IgG deposits that were increased with apoferritin treatment remained unchanged, while the glomeruli looked closer to normal on macrophage depletion.

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(b)

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