lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p

<div>Ectopic expression of DLEU1 induced chondrocyte viability, degradation of ECM, and inflammation mediator secretion. (a) The expression of DLEU1 was measured by qRT-PCR analysis. (b) Ectopic expression of DLEU1 promoted cell viability in the chondrocytes using CCK-8 assay. (c) Elevated expression of DLEU1 suppressed collagen II expression in the chondrocytes. (d) The expression of aggrecan was detected by qRT-PCR assay. (e) Overexpression of DLEU1 induced ADAMTS-5 expression in the chondrocytes. (f) The expression of MMP-3 was measured by qRT-PCR assay. (g) DLEU1 overexpression promoted IL-6 expression in the chondrocytes using ELISA. (F) The expression of IL-8 was measured by ELISA. 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Journal of Immunology Research

fig6

Figure 6

Figure 6: lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p 