lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p

<div>Elevated expression of miR-671-5p suppressed chondrocyte viability, degradation of ECM, and inflammation mediator secretion. (a) The expression of miR-671-5p was measured by qRT-PCR analysis. (b) Ectopic expression of miR-671-5p inhibited cell viability in the chondrocytes using CCK-8 assay. (c) Elevated expression of miR-671-5p enhanced collagen II expression in the chondrocytes. (d) The expression of aggrecan was detected by qRT-PCR assay. (e) Overexpression of miR-671-5p suppressed ADAMTS-5 expression in the chondrocytes. (f) The expression of MMP-3 was measured by qRT-PCR assay. (g) miR-671-5p overexpression inhibited IL-6 expression in the chondrocytes using ELISA. (h) The expression of IL-8 was measured by ELISA. 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Journal of Immunology Research

fig7

Figure 7

Figure 7: lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p 