Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis

Figure 3

Coexpression of ER stress marker and NLRP3 inflammasome-related proteins in type II alveolar epithelial cells in BLM-induced pulmonary fibrosis. Immunofluorescence staining showing (a, b) colocalization of SPC with the ER stress marker CHOP and the NLRP3 inflammasome-related protein NLRP3 and (c, d) colocalization of the ER stress marker CHOP with the NLRP3 inflammasome-related protein NLRP3 and IL-1β.

(a)

(b)

(c)

(d)