Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis

<div>Upregulation of the cAMP/PKA pathway in BLM-induced pulmonary fibrosis. (a) Immunohistochemical staining of PKA protein. Immunofluorescence staining showing colocalization of (b, c) SPC/PKA and SPC/cAMP and (d) cAMP/NLRP3.</div>

Journal of Immunology Research

fig5

Figure 5

Figure 5: Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis 

Figure 5 | Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis 