Significance of Immune-Related Genes in the Diagnosis and Classification of Intervertebral Disc Degeneration

Figure 5

(a) Consensus clustering in the “ConsensusClusterPlus” package was used to identify different immune patterns (immune clusters A and B) on the basis of 11 IRGs. (b) Differential expression levels between the 11 significant IRGs between the two clusters are shown by histograms, and the results suggested that CTSS, STAT3, FPR1, C5AR2, IFGR2, and IL17RA displayed higher expression levels in immune cluster B than in immune cluster A, while RLN1 showed the opposite. S100Z, KLRK1, IL2RB, and IL6R demonstrated no significant differences between immune cluster A and B. (c) 11 significant IRGs can completely distinguished the two patterns by the PCA algorithm. (d) The GO functional enrichment analysis and the enrichment circle plot visualization results were used to understand the possible mechanism of the different immune patterns in IDD.

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