Arsenic Trioxide Cooperate Cryptotanshinone Exerts Antitumor Effect by Medicating Macrophage Polarization through Glycolysis

Figure 7

(a) Regulation of NF-κB/HIF-1α signaling pathway by ACCS. (b–d) Activation of NF-κB/HIF-1α signaling pathway after ACCS intervention in primary M0 macrophages. (e–g) Activation of NF-κB/HIF-1α signaling pathway after ACCS intervention in tumor-like M2-type macrophages. (h) Regulation of AMPK signaling pathway by ACCS. (i) Activation of the AMPK signaling pathway after ACCS intervention in primary M0 macrophages. (j) Activation of AMPK signaling pathway after ACCS intervention in tumor-like M2-type macrophages. (k–m) Expression of LA in supernatant and protein level of Glut1 after AMPK blockade and activation.

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