Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population
Table 2
Distribution frequency of SNPs of ASAP1 and SP110 gene in TB and healthy population.
Gene
SNP
Genotypes
TB ()
Control ()
value
Univariate logistic model
OR (95 CI)
value
ASAP1
rs10956514
GG
59 (29.9)
61 (28.1)
0.234
0.889
1.00 (ref)
GA
107 (54.3)
119 (54.8)
0.93 (0.60, 1.45)
0.747
AA
31 (15.7)
37 (17.1)
0.87 (0.48, 1.57)
0.637
rs4733781
CC
61 (31.0)
61 (29.5)
0.432
0.806
1.00 (ref)
CA
104 (52.8)
118 (55.8)
0.88 (0.57, 1.37)
0.576
AA
61 (31.0)
61 (29.5)
0.84 (0.47, 1.52)
0.568
rs2033059
TT
61 (31.0)
61 (28.1)
0.432
0.806
1.0 (ref)
TC
104 (52.8)
118 (54.4)
0.88 (0.57, 1.37)
0.576
CC
32 (16.2)
38 (17.5)
0.84 (0.47, 1.52)
0.568
rs12680942
GG
62 (31.5)
61 (28.1)
0.636
0.727
1.0 (ref)
GA
104 (52.8)
118 (54.4)
0.87 (0.56, 1.35)
0.526
AA
31 (15.7)
38 (17.5)
31 (15.7)
38 (17.5)
0.8 (0.44, 1.45)
0.466
rs1469288
AA
60 (30.5)
60 (27.6)
0.496
0.780
1.0 (ref)
AG
106 (53.8)
119 (54.9)
0.89 (0.57, 1.39)
0.609
GG
31 (15.7)
38 (17.5)
31 (15.7)
38 (17.5)
0.82 (0.45, 1.48)
0.502
rs17285138
AA
62 (31.5)
61 (28.1)
0.636
0.727
1.0 (ref)
AT
104 (52.8)
118 (54.4)
0.87 (0.56, 1.35)
0.526
TT
31 (15.7)
38 (17.5)
0.8 (0.44, 1.45)
0.466
SP110
rs1135791
AA
137 (69.5)
156 (71.9)
1.696
0.428
1.0 (ref)
AG
55 (27.9)
59 (27.2)
1.06 (0.69, 1.64)
0.787
GG
5 (2.5)
2 (0.9)
2.85 (0.54, 14.91)
0.216
rs9061
CC
135 (68.5)
139 (64.1)
1.002
0.606
1.0 (ref)
CT
58 (29.4)
72 (33.2)
0.83 (0.55, 1.26)
0.382
TT
4 (2.0)
6 (2.8)
0.69 (0.19, 2.49)
0.567
rs722555
CC
61 (31)
95 (43.8)
7.327
0.026
1.0 (ref)
CT
106 (53.8)
93 (42.9)
1.78 (1.16, 2.72)
0.008
TT
30 (15.2)
29 (13.4)
1.61 (0.88, 2.95)
0.121
rs3948464
GG
197 (100)
213 (98.2)
3.667
0.074
NA
GA
0
4 (1.8)
1.0 (ref)
AA
0
0
0
0
NA
rs11679983
GG
181 (91.9)
195 (89.9)
0.504
0.296
1.0 (ref)
GA
16 (8.1)
22 (10.1)
0.78 (0.4, 1.54)
0.479
AA
0
0
NA
rs1365776
TT
150 (76.1)
167 (77)
0.985
0.619
1.0 (ref)
TC
46 (23.4)
47 (21.7)
2.94 (0.29, 29.27)
0.359
CC
1 (0.5)
3 (1.4)
2.69 (0.28, 26.18)
0.393
rs11556887
GG
166 (84.3)
188 (86.6)
0.469
0.293
1.0 (ref)
GA
31 (15.7)
29 (13.4)
1.21 (0.7, 2.09)
0.494
AA
0
0
NA
Data are presented as (%). SNP: single-nucleotide polymorphism; TB: tuberculosis; OR: odds ratio; CI: confidence intervals; ref: reference; NA: not applicable. values below 0.05 are highlighted in bold.
