Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population
Table 4
Analysis of the inheritance models of ASAP1 and SP110 polymorphism associated with tuberculosis.
Gene
SNP
Model
Genotype
TB, (%)
Control, (%)
Univariate logistic model
OR (95 CI)
value
ASAP1
rs10956514
Dominant
G/G G/A-A/A
59 (29.9) 138 (70.1)
61 (28.1) 156 (71.9)
0.91 (0.60, 1.40)
0.681
Recessive
G/G-G/A A/A
166 (84.3) 31 (15.7)
180 (82.9) 37 (17.1)
0.91 (0.54, 1.53)
0.718
Additive
G/G A/A
59 (29.9) 31 (15.7)
61 (28.1) 37 (17.1)
0.87 (0.48, 1.57)
0.637
rs4733781
Dominant
C/C A/C-A/A
61 (31.0) 136 (69.0)
61 (28.1) 156 (71.9)
0.87 (0.57, 1.33)
0.525
Recessive
C/C-A/C A/A
165 (83.8) 32 (16.2)
179 (82.5) 38 (17.5)
0.91 (0.55, 1.53)
0.731
Additive
C/C A/A
61 (31.0) 32 (16.2)
61 (28.1) 38 (17.5)
0.84 (0.47, 1.52)
0.568
rs2033059
Dominant
T/T C/T-C/C
61 (31.0) 136 (69.0)
61 (28.1) 156 (71.9)
0.87 (0.57, 1.33)
0.525
Recessive
T/T-C/T C/C
165 (83.8) 32 (16.2)
179 (82.5) 38 (17.5)
0.91 (0.55, 1.53)
0.731
Additive
T/T C/C
61 (31.0) 32 (16.2)
61 (28.1) 38 (17.5)
0.84 (0.47, 1.52)
0.568
rs12680942
Dominant
G/G A/G-A/A
62 (31.5) 135 (68.5)
61 (28.1) 156 (71.9)
0.85 (0.56, 1.30)
0.455
Recessive
G/G-A/G A/A
166 (84.3) 31 (15.7)
179 (82.5) 38 (17.5)
0.88 (0.52, 1.48)
0.628
Additive
G/G A/A
62 (31.5) 31 (15.7)
61 (28.1) 38 (17.5)
0.80 (0.44, 1.45)
0.466
rs1469288
Dominant
A/A G/A-G/G
60 (30.5) 137 (69.5)
60 (27.6) 157 (72.4)
0.87 (0.57, 1.33)
0.530
Recessive
A/A-G/A G/G
166 (84.3) 31 (15.7)
179 (82.5) 38 (17.5)
0.88 (0.52, 1.48)
0.628
Additive
A/A G/G
60 (30.5) 31 (15.7)
60 (27.6) 38 (17.5)
0.82 (0.45, 1.48)
0.502
rs17285138
Dominant
A/A T/A-T/T
62 (31.5) 135 (68.5)
61 (28.1) 156 (71.9)
0.85 (0.56, 1.30)
0.455
Recessive
A/A-T/A T/T
166 (84.3) 31 (15.7)
179 (82.5) 38 (17.5)
0.88 (0.52, 1.48)
0.628
Additive
A/A T/T
62 (31.5) 31 (15.7)
61 (28.1) 38 (17.5)
0.80 (0.44, 1.45)
0.466
SP110
rs1135791
Dominant
A/A A/G-G/G
137 (69.5) 60 (30.5)
156 (71.9) 61 (28.1)
1.12 (0.73, 1.71)
0.600
Recessive
A/A-A/G G/G
192 (97.5) 5 (2.5)
215 (99.1) 2 (0.9)
2.80 (0.54, 14.60)
0.222
Additive
A/A G/G
137 (69.5) 5 (2.5)
156 (71.9) 2 (0.9)
2.85 (0.54, 14.91)
0.216
rs9061
Dominant
C/C C/T-T/T
135 (68.5) 62 (31.5)
139 (64.1) 78 (35.9)
0.82 (0.54, 1.23)
0.337
Recessive
C/C-C/T T/T
193 (98.0) 4 (2.0)
211 (97.2) 6 (2.8)
0.73 (0.20, 2.62)
0.628
Additive
C/C T/T
135 (68.5) 4 (2.0)
139 (64.1) 6 (2.8)
0.69 (0.19, 2.49)
0.567
rs722555
Dominant
C/C C/T-T/T
61 (31.0) 136 (69.0)
95 (43.8) 122 (56.2)
1.74 (1.16, 2.60)
0.007
Recessive
C/C-C/T T/T
167 (84.8) 30 (15.2)
188 (86.6) 29 (13.4)
1.16 (0.67, 2.02)
0.588
Additive
C/C T/T
61 (31.0) 30 (15.2)
95 (43.8) 29 (13.4)
1.61 (0.88, 2.95)
0.121
rs3948464
Dominant
G/G G/A-AA
197 (100.0) 0 (0.0)
213 (98.2) 4 (1.8)
NA
Recessive
G/G-G/A AA
197 (100.0) 0 (0.0)
217 (100.0) 0 (0.0)
NA
Additive
G/G AA
197 (100.0) 0 (0.0)
213 (98.2) 0 (0.0)
NA
rs11679983
Dominant
G/G G/A-AA
181 (91.9) 16 (8.1)
195 (89.9) 22 (10.1)
0.78 (0.40, 1.54)
0.479
Recessive
G/G-G/A AA
197 (100.0) 0 (0.0)
217 (100.0) 0 (0.0)
NA
Additive
G/G AA
181 (91.9) 0 (0.0)
195 (89.9) 0 (0.0)
NA
rs1365776
Dominant
T/T C/T-C/C
150 (76.1) 47 (23.9)
167 (77.0) 50 (23.0)
1.05 (0.66, 1.65)
0.845
Recessive
T/T-C/T C/C
196 (99.5) 1 (0.5)
214 (98.6) 3 (1.4)
0.36 (0.04, 3.53)
0.383
Additive
T/T C/C
150 (76.1) 1 (0.5)
167 (77.0) 3 (1.4)
0.37 (0.04, 3.61)
0.393
rs11556887
Dominant
GG GA-AA
166 (84.3) 31 (15.7)
188 (86.6) 29 (13.4)
1.21 (0.70, 2.09)
0.494
Recessive
G/G-GA A/A
197 (100.0) 0 (0.0)
217 (100.0) 0 (0.0)
NA
Additive
GG A/A
166 (84.3) 0 (0.0)
188 (86.6) 0 (0.0)
NA
Data are presented as (%). SNP: single-nucleotide polymorphism; TB: tuberculosis; OR: odds ratio; CI: confidence intervals; NA: not applicable. values below 0.05 are highlighted in bold.
