Profiling Serum Cytokines and Anticytokine Antibodies in Psoriasis Patients

Figure 4

Bioactivities of serum IL-17A were correlated with psoriasis severity. (a) Primary keratinocytes (PKC) were cocultured with serum diluted in 10% in the presence and absence of anti-IL-17A antibodies. IL-8 in medium was measured by ELISA 24 hours later. (b) The comparison of the PASI score between patients with or without bioactive IL-17A in serum. (c) Correlation analysis between PASI score and the percentage of the decreased levels of IL-8 (ΔIL-8) relative to those cultured with serum. Data are presented as and compared by the Mann–Whitney test in (b) and Spearman’s correlation test in (c). ns: not significant.

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(b)

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