Sushi-Repeat-Containing Protein X-Linked 2: A Potential Therapeutic Target for Inflammation and Cancer Therapy

Table 1

Roles for SRPX2 in cancer metastasis, invasion, migration, drug resistance, and prognosis.

Cancer type	Downstream signaling pathway	Upstream signaling pathway	Effects	Prognostic value	References
Gastric cancer	FAK	/	Migration and adhesion induction	Lower OS and worse prognosis; independent predictor of outcomes	[15, 27]
Colorectal cancer	Wnt/β-catenin pathway-mediated MMP2/9	miR-192, miR-215, miR-149	Invasion induction	/	[16]
Pancreatic ductal adenocarcinoma	FAK; PI3K/AKT/mTOR	/	Migration and adhesion induction; 5-Fu and gemcitabine resistance	Shorter DFS and OS	[17, 34, 52]
Prostate cancer	PI3K/Akt/mTOR	/	Migration and adhesion induction	Shorter OS	[7, 53]
Oral squamous cell carcinomas	/	LEMD1	Adhesion induction; nedaplatin and cisplatin resistance	/	[10]
Glioblastoma	p-ERK, p-JNKp38	/	Metastasis induction; temozolomide resistance	/	[18]
Hepatocellular carcinoma	FAK/AKT pathway-mediated MMP2/9	/	Metastasis induction	/	[19]
Osteosarcoma	Yes-associated protein (YAP)	/	Invasion induction	/	[38]
Esophageal squamous cell carcinoma	Wnt/β-catenin	/	Metastasis induction; cisplatin resistance	/	[39]
Papillary thyroid cancer	/	/	/	Independent prognostic factor	[54]