ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages

Figure 5

Mechanism of A disintegrin and metalloprotease 10 (ADAM-10) regulation of matrix metalloproteinase 12 (MMP-12) in lipopolysaccharide-promoted proliferation- (LPS-) induced macrophages. LPS promotes macrophage inflammatory responses. Intracellular pro-ADAM-10 is processed into ADAM-10. Additionally, ADAM-10 protein secretion is increased. In this process, ADAM-10 promotes MMP-12 expression, which is jointly related to the LPS-induced inflammatory response.