Tacrolimus Concentration Is Effectively Predicted Using Combined Clinical and Genetic Factors in the Perioperative Period of Kidney Transplantation and Associated with Acute Rejection
Table 1
Demographic characteristics of kidney transplant recipients and donors.
Recipients
Gender (male)
178 (69.5)
Age (years), median (IQR)
41 (34-50)
BMI, median (IQR)
22.59 (20.21-24.82)
Postoperative day (IQR)
16 (10-32)
Comorbidity, (%)
Hypertension
187 (73.0)
Anemia
117 (45.7)
Hepatitis B
14 (5.5)
Diabetes
12 (4.7)
Anterolisthesis
6 (2.3)
Coronary heart disease
4 (1.6)
Others Laboratory findingsa, median (IQR)
4 (1.6)
White blood cell count (×109/L)
6.92 (5.2-9.03)
Red blood cell count (×109/L)
3.02 (2.59-3.53)
Hemoglobin (g/L)
91.0 (79.0-105.0)
Hematocrit (%)
27.2 (23.5-32.0)
Platelet count (×109/L)
179.0 (142.0-230.0)
Neutrophil count (×109/L)
5.34 (3.87-7.24)
Total bilirubin (μmol/L)
8.4 (6.5-11.17)
ALT (U/L)
26.0 (17.0-37.0)
AST (U/L)
16.0 (13.0-20.0)
ALP (U/L)
62.0 (47.0-82.0)
TP (g/L)
62.1 (57.02-69)
ALB (g/L)
39.0 (34.9-43.5)
BUN (mmol/L)
10.84 (7.62-16.97)
Cre (μmol/L)
835.3 (700.75-916.78)
Uric acid (μmol/L)
325.1 (253.45-411.6)
Immunosuppression regimens
Induction agent, (%)
Basiliximab
32 (12.5)
Antithymocyte globulin
224 (87.5)
Antiproliferative agent, (%)
Mycophenolate
239 (93.4)
Azathioprine
17 (6.6)
Donors
Gender (male)
175 (68.4)
Age (years), median (IQR)
49 (37-59)
BMI, median (IQR)
24.2 (21.5-29.6)
aThe first day after kidney transplantation. BMI: body mass index; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; TP: total protein; ALB: albumin; BUN: blood urea nitrogen; Cre: creatinine.
