Cortistatin-14 Exerts Neuroprotective Effect Against Microglial Activation, Blood-brain Barrier Disruption, and Cognitive Impairment in Sepsis-associated Encephalopathy

Figure 2

Cortistatin improved overall survival and cognitive and emotional impairement of CLP-induced sepsis in mice. (a) Survival curve. Four of 14 mice of the CLP group survived on day 7. Eight of 12 mice of the cortistatin group survived. (b)–(d) Time spent with a novel object, contacts with the novel object, and preference index in the novel object recognition test, respectively. (e),and (f) Entries of the open arms and time consumed in the open arms in the elevated plus maze test, respectively. (g) Total immobility time during 5 min in the tail suspension test. (h) Percentage of center duration in the 5 min in the open field test. Data were shown as mean ± standard deviation (n = 8 per group). P < 0.05 and P < 0.01.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)